Contributors to Cancer Susceptibility, Development and Treatment: Cyclic Nucleotides, Steroids and Autophagy Modulators

Cell autophagy and apoptosis processes are of interest in drug development contribute to the chemotherapy outcomes patients receiving cancer treatment. The functional roles cyclic nucleotides cells include maintenance metabolic homeostasis. cGMP steroid compounds participate apoptotic autophagic events, modulate function multi-drug resistance proteins. Endogenous nucleotide ratios change with ageing this may initiate detrimental changes cell function. This study uses a computational chemistry approach investigate molecular similarity within chemotherapeutic compound structures. Modulators autophagy/apoptosis endogenous structures all demonstrate structure cGMP. Relative these facilitates additive synergistic treatment effects. steroids natural modulators apoptosis; concentration consequently have potential impact risks.